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Current Clinical Trials
Sponsor: Sirion Therapeutics
Protocol: ST-601A-001; A Phase 2b Multicenter, Randomized, Double-Masked Study of the Safety and Efficacy of Difluprednate 0.05% Ophthalmic Emulsion Compared to Prednisolone Acetate 1% Ophthalmic Suspension in the Treatment of Endogenous Anterior Uveitis
Incl. Criteria:
- The presence of >10 (11 or more) cells in the AC of at least one eye
- A Flare score of >2 in that same eye
- Diagnosis of endogenous anterior uveitis in at least 1 eye.
Exc. Criteria:
- Presence of intermediate uveitis, posterior uveitis or panuveitis
- IOP >24mm Hg
- Corneal abrasion or ulceration
- New administration or any change in dosage of any corticosteroid or immunosuppressive drug, including inhaled, nasal, or dermatological steroids in the 2 weeks prior to study enrollment
Status: Actively Enrolling
Principal Investigator: Michael B. Raizman, M.D.
Contact Person: Jacqueline Pereira @ 617-573-1027
Sponsor: Ista Pharmaceutical, Inc.
Protocol: CL-S&E-1107071-P; A Multi-Center, Double-Blind Vehicle-Controlled, Randomized Study of Ecabet Ophthalmic Solution in Patients with Dry Eye Disease
Incl. Criteria: IOP >5 and <22mm Hg in each eye
- Best Corrected VA 20/40 with pinhole or better in each eye
- Have a diagnosis of dry eye
Exc. Criteria:
- Diagnosis of Sjogrens syndrome;lacrimal obstruction; pemphigoid; significant anterior blepharitis or meibomianitis; chronic systemic inflammation (i.e. rheumatoid arthritis, systemic lupus)
- History of ocular herpetic keratitis
- Use of contact lenses during the study
- Dry eye secondary to surgery
Status: Actively Enrolling
Principal Investigator: Peter A. Rapoza, M.D. (Michael B. Raizman, MD-Sub-Investigator)
Contact Person: Astrid Rapoza @ 617-314-2674
Sponsor: AMO
Protocol: Blink; Single Center Open Label Pilot Study Evaluating Blink Lubricant Eye Drops in Postoperative Cataract Surgery Patients
Incl. Criteria:
- Presence of a posterior chamber monofocal or multifocal intraocular lens in the study eye
- Snellen acuity in study eye of 20/60 or better on post-operative Day 1
Exc. Criteria:
- Active inflammation in the study eye beyond what is expected on Day 1 after cataract surgery
- History of dry eye disease
- History of contact lenses in the study eye in the past 4 weeks
- Abnormal lid closure in the study eye
Status: Actively Enrolling
Principal Investigator: Michael B. Raizman, M.D.
Contact Person: Jacqueline Pereira @ 617-573-1027
Sponsor: Itherapeutix
Protocol: Evaluation of the I-ZIP Ocular Bandage system as a protective ocular bandage in subjects undergoing cataract surgery with IOL implantation
Incl. Criteria:
- Older that 18 years of age
- Subject has a cataract and is expected to undergo unilateral clear corneal cataract surgery with phacoemulsification and implantation of a posterior chamber monofocal intraocular lens via an incision <3.5mm in length
Exc. Criteria:
- Subject not suitable for topical anesthesia
- Any intraocular inflammation in the study eye that was present during the screening slit-lamp examination
- BCVA in fellow worse than 20/40
Status: In regulatory start-up process
Principal Investigator: Michael B. Raizman, MD
Contact Person: Jacqueline Pereira @ 617-573-1027
Sponsor: Eyegate Pharmaceuticals, Inc.
Protocol: EGP-437-001; A Prospective, Multi-Center, Randomized, Double-Masked, Safety, Tolerability and Efficacy Study of Four Iontophoretic Doses of Dexamethasone Phosphate Ophthalmic Solution in Patient with Non-Infectious Acute Anterior Segment Uveitis
Incl. Criteria:
- A diagnosis of non-infectious acute anterior uveitis defined as an anterior chamber cell score >1.5
- Male or female patients age 18 to 85
Exc. Criteria:
- Bilateral uveitis
- IOP >25mm Hg at baseline
- Patients who have received treatment for any type of uveitis in either eye within 4 weeks of presentation for enrollment
- Intermediate or posterior uveitis
- History of diagnosis of ocular herpes, or corneal lesion of suspected herpetic origin
Status: Actively Enrolling
Principal Investigator: Michael B. Raizman, MD
Contact Person: Jacqueline Pereira @ 617-573-1027
Sponsor: Rapid Pathogen Screening, Inc.
Protocol: A Single-Center Study Comparing the Sensitivity and Specificity of the Rapid Pathogen Screening Detector to the Clinical Exam in evaluating the presence and severity of Allergic Conjunctivitis in Cat-Sensitive Individuals
Incl. Criteria:
- Subject has a documented history of ocular allergy to cats which includes a history of eye itching during previous exposures
Exc. Criteria:
- Use of any topical or systemic corticosteroids, immunosuppressive agents, antihistamines, decongestants, NSAIDs or aspirin during the two weeks prior to enrollment into the study
- A history of severe asthma, reactive airway disease or bronchial obstruction, especially when exposed to cat dander
- Use of contact lenses during the study
Status: In regulatory start-up process
Principal Investigator: Michael B. Raizman, MD
Contact Person: Jacqueline Pereira @ 617-573-1027
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